Centre for disease and control(CDC) define malaria as a mosquito-born disease caused by a parasite. People that suffers malaria often experience fever, chills and flu-like illness. Left untreated, they may develop severe complications and die. In 2010, an estimated 219 million cases of malaria occurred worldwide and 660,000 people died most(91 per cent) in the African region. In the same vein,WHO, saidy malaria is a deadly killer The disease kills more than one million children-2,800 per day- each year in Africa alone. In regions of intense transmission, 40 per cent of toddlers die of acute malaria.
 malaria is serious disease spread by certain mosquitoes malaria is caused by a protozoan if the plasmodium in the red blood cells which is transmitted to humans by the bite of an infected anopheles mosquito. thud mosquitoes has been discovered since the 15th century BC. it is most common in tropicals and sub-tropicals near swamps. malaria kills twice as AIDS. as many as a billion people worldwide are left with chronic anaemia due to malaria infection. the spread of malaria is becoming more serious than before as its parasites develop resistance to the drugs used to treat the condition.

>> see zika virus(aedes mosquitoes)

 symptoms and signs:
 the scourge if the malaria and the parasite were proved in early 20th century. annual cases worldwide are estimated at 250 million and death at 2 million. malaria from different plasmodium species differs in severity, molarity and geographical distribution. the parasites have an extremely complex life cycle. in a stage they develop synchronously inside red blood cells. their mass fission at 48 or 72 hours intervals cause attacks lasting 4-10 hours. shaking and chills are followed by fever up to 105°F (40.6°C) with severe headache and then profuse sweating as temperature returns to normal. patients often have anaemia, spleen enlargement, and general weakness.
 malaria is diagnosed by the parasite in the blood. initially, Quinine was long used to alleviate the fevers. systhetic drugs such as chloroquine, destroy the parasite in the blood cells. but many strains are now resistant, carriers of gene for a hemoglobinopathy have natural resistance. (hemoglobinopathies are genetic disorders of hemoglobin, the oxygen carrying protein of the red blood cells).
 scientists believe it may be possible to combat malaria by interfering with the sex lives of the mosquitoes which spread the disease. they have shown that the insect can only mate successfully if the male us able to seal his sperm inside the female using a mating plug. without the plug , fertilization cannot occur, and the insect cannot reproduce. these insects mate only once in their lifetime i.e the anopheles gambiae, so disrupting the reproductive process offers a good way of dramatically reducing their numbers. when they mate, the male transfers sperm to the female followed by a coagulated mass of proteins and seminal fluids. this fluids or mating plug is not found in any other species of mosquitoes and its role has previously been unclear. in the lab, the researchers were able to stop successful reproduction by preventing the formation of the plug in males

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